SMG1 polyclonal antibody
产品名称： SMG1 polyclonal antibody
英文名称： SMG1 polyclonal antibody
产品编号： PAB3258
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SMG1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SMG1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.
Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT.Mol Cell. 2004 Jun 4;14(5):585-98.
- 2.
- The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.
Abraham RT.DNA Repair (Amst). 2004 Aug-Sep;3(8-9):919-25.
- 3.
- Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S.Genes Dev. 2001 Sep 1;15(17):2215-28.
- Entrez GeneID:
- 23049
- Protein Accession#:
- NP_055907;Q96Q15
- Gene Name:
- SMG1
- Gene Alias:
- 61E3.4,ATX,KIAA0421,LIP
- Gene Description:
- SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
- Omim ID:
- 607032
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq
- Other Designations:
- PI-3-kinase-related kinase SMG-1,lambda/iota protein kinase C-interacting protein,phosphatidylinositol 3-kinase-related kinase,phosphatidylinositol 3-kinase-related protein kinase