FITC标记的肿瘤坏死因子受体超家族成员9抗体
产品名称： FITC标记的肿瘤坏死因子受体超家族成员9抗体
英文名称： Anti-CD137/FITC
产品编号： HZ-2449R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CD137/FITC Conjugated antibody
FITC标记的肿瘤坏死因子受体超家族成员9抗体
| 英文名称 | Anti-CD137/FITC |
| 中文名称 | FITC标记的肿瘤坏死因子受体超家族成员9抗体 |
| 别 名 | Tumor necrosis factor receptor superfamily member 9; Tnfrsf9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; Cd137; CDw137; CD 137; CD137 antigen; Induced by lymphocyte activation; ILA; Interleukin activated receptor homolog of mouse Ly63; Ly63; MGC2172; MGC114552; OTTHUMP00000044294; TNR9_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞凋亡 细胞膜受体 自然杀伤细胞 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD137 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Subunit: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on the surface of activated T-cells. Similarity: Contains 4 TNFR-Cys repeats. Database links: Entrez Gene: 3604 Human Omim: 602250 Human SwissProt: Q07011 Human Unigene: 654459 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD137属于肿瘤坏死因子超家族成员，是可诱导的T细胞共刺激受体，表达于CD4 + 和CD8 + T细胞、活化的自然杀伤细胞（natural killercell，NK）和树突状细胞,CD137可抑制T细胞增殖，诱发细胞凋亡 |
CD137作为分子量为30 kDa的单体和55 kDa的二聚体存在于细胞表面。人和小鼠CD137共有60%个氨基酸的同源性。肿瘤坏死因子受体超家族成员CD137（4-1BB）是一种在活化的脾T细胞和胸腺细胞表面表达的I型跨膜糖蛋白。CD137在T淋巴细胞中的功能包括调节活化、增殖和凋亡。CD137和CD28是T细胞活化的共刺激分子。共刺激分子在抗肿瘤免疫应答中起着重要作用。CD137在调节T细胞依赖性免疫应答中起重要作用。CD137的表达与淋巴细胞增殖呈负相关，与由丝裂原过度刺激引起的活化诱导的细胞死亡程度呈正相关。在单核细胞中，CD137诱导活化，促进粘附并延长生存期。